Inhaled Technosphere® Insulin in Comparison to Subcutaneous Regular Human Insulin: Time Action Profile and Variability in Subjects with Type 2 Diabetes
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چکیده
منابع مشابه
Inhaled Technosphere insulin in comparison to subcutaneous regular human insulin: time action profile and variability in subjects with type 2 diabetes.
BACKGROUND This study assessed time action profile and within- and between-subject variability of inhaled Technosphere Insulin (TI) compared with subcutaneous regular human insulin (sc RHI). METHODS Thirteen subjects with type 2 diabetes (age 56 +/- 7 years, body mass index 30.4 +/- 3.0 kg.m(-2); hemoglobin A1c 6.9 +/- 0.9%; mean +/- SD) participated in this six-period crossover isoglycemic g...
متن کاملCoverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes.
T echnosphere Insulin (TI) is a formulation of regular human insulin (RHI) that provides efficient pulmonary administration (1) and demonstrates unique pharmacokinetic and pharmacodynamic properties compared with subcutaneous RHI, rapid-acting insulin analogs, and other inhaled insulins (2). Administration of TI results in a time to maximum insulin concentration of 15 min, with almost complete ...
متن کاملOral Insulin: A Comparison With Subcutaneous Regular Human Insulin in Patients With Type 2 Diabetes
OBJECTIVE To determine the pharmacokinetic and pharmacodynamic properties of an oral insulin (OI) formulation compared with subcutaneously injected regular human insulin (RHI). RESEARCH DESIGN AND METHODS Ten male patients with type 2 diabetes (means +/- SD; A1C 7.0 +/- 1.1%; BMI 28.3 +/- 2.7 kg/m(2)) received either 300 units of insulin combined with 400 mg of delivery agent orally or 15 uni...
متن کاملTime-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin.
OBJECTIVE This study compares the time-action profile of inhaled insulin (INH; Exubera) with that of subcutaneously injected insulin lispro (ILP) or regular human insulin (RHI) in healthy volunteers. RESEARCH DESIGN AND METHODS In this open-label, randomized, three-way, crossover study, 17 healthy male volunteers were given each of the following treatments in random order: INH (6 mg), ILP (18...
متن کاملInhaled Technosphere Insulin Versus Inhaled Technosphere Placebo in Insulin-Naı̈ve Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetes Agents
TI significantly reduced HbA1c by20.8% (29.0 mmol/mol) from a baseline of 8.3% (66.8 mmol/mol) compared with TP 20.4% (24.6 mmol/mol) (treatment difference 20.4% [95% CI 20.57, 20.23]; P < 0.0001). More TI-treated subjects achieved an HbA1c £7.0% (53.0 mmol/mol) (38% vs. 19%; P = 0.002). Mean fasting plasma glucosewas similarly reduced in both groups. Postprandial hyperglycemia, based on 7-poin...
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ژورنال
عنوان ژورنال: Journal of Diabetes Science and Technology
سال: 2008
ISSN: 1932-2968,1932-2968
DOI: 10.1177/193229680800200206